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J Clin Invest. 2012 Aug;122(8):2724-30. doi: 10.1172/JCI60519. Epub 2012 Aug 1.

Building and maintaining the epithelium of the lung.

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1
Pulmonary, Allergy and Critical Care, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Abstract

Airspaces of the lung are lined by an epithelium whose cellular composition changes along the proximal-to-distal axis to meet local functional needs for mucociliary clearance, hydration, host defense, and gas exchange. Advances in cell isolation, in vitro culture techniques, and genetic manipulation of animal models have increased our understanding of the development and maintenance of the pulmonary epithelium. This review discusses basic cellular mechanisms that regulate establishment of the conducting airway and gas exchange systems as well as the functional maintenance of the epithelium during postnatal life.

PMID:
22850882
PMCID:
PMC3408736
DOI:
10.1172/JCI60519
[Indexed for MEDLINE]
Free PMC Article
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