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J Clin Invest. 2012 Aug;122(8):2711-9. doi: 10.1172/JCI62423. Epub 2012 Aug 1.

Alarmins: awaiting a clinical response.

Author information

1
Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom. james.chan@kennedy.ox.ac.uk

Abstract

Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes seen in many inflammatory and autoimmune conditions, as well as tumorigenesis and cancer spread. Conversely, alarmins have also been found to play a major role in the orchestration of tissue homeostasis, including repair and remodeling in the heart, skin, and nervous system. Here, we provide an update and overview on alarmins, highlighting the areas that may benefit from this clinical translation.

PMID:
22850880
PMCID:
PMC3408740
DOI:
10.1172/JCI62423
[Indexed for MEDLINE]
Free PMC Article
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