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Nat Rev Mol Cell Biol. 2012 Sep;13(9):566-78. doi: 10.1038/nrm3412. Epub 2012 Aug 1.

Mitochondria as sensors and regulators of calcium signalling.

Author information

1
Department of Biomedical Sciences, University of Padua and CNR Neuroscience Institute, Via G. Colombo 3, 35131 Padua, Italy. rosario.rizzuto@unipd.it

Abstract

During the past two decades calcium (Ca(2+)) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance. Mitochondrial Ca(2+) uptake was shown to control intracellular Ca(2+) signalling, cell metabolism, cell survival and other cell-type specific functions by buffering cytosolic Ca(2+) levels and regulating mitochondrial effectors. Recently, the identity of mitochondrial Ca(2+) transporters has been revealed, opening new perspectives for investigation and molecular intervention.

PMID:
22850819
DOI:
10.1038/nrm3412
[Indexed for MEDLINE]

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