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Arch Pathol Lab Med. 2012 Aug;136(8):901-6. doi: 10.5858/arpa.2012-0165-CR.

Tenosynovial giant cell tumor: case report and review.

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Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.


Tenosynovial giant cell tumors are a group of generally benign intra-articular and soft tissue tumors with common histologic features. They can be roughly divided into localized and diffuse types. Localized types include giant cell tumors of tendon sheath and localized pigmented villonodular synovitis, whereas diffuse types encompass conventional pigmented villonodular synovitis and diffuse-type giant cell tumor. Localized tumors are generally indolent, whereas diffuse tumors are locally aggressive. Recent developments indicate that tenosynovial giant cell tumors are clonal neoplastic tumors driven by overexpression of CSF1. Herein, I report a case of intra-articular, localized tenosynovial giant cell tumor (or localized pigmented villonodular synovitis) and review the classification, histopathology, and recent developments regarding its pathogenesis.

[Indexed for MEDLINE]

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