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J Bioinform Comput Biol. 2012 Oct;10(5):1271001. doi: 10.1142/S0219720012710011. Epub 2012 Jun 22.

A decade after the first full human genome sequencing: when will we understand our own genome?

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Bioinformatics Institute-BII, Agency for Science, Technology and Research-A*STAR, 30 Biopolis Street, #07-01, Matrix, Singapore 138671, Singapore.


The contrast between the pomp of celebrating the first full human genome sequencing in 2000 and the cautious tone of recollections a decade thereafter could hardly be greater. The promises with regard to medical cures and biotechnology applications have been realized not even nearly to the expectations. Understanding the human genomes means knowing the genes' and proteins' functions and their interconnectedness via biomolecular mechanisms. This articles estimates how long will it take to achieve this goal if we extrapolate from the previous decade (indeed, a century!) and the possible disruptive trends in science, technology and society that may accelerate the pace of progress dramatically.

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