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BMC Biol. 2012 Jul 31;10:66. doi: 10.1186/1741-7007-10-66.

Folate status of gut microbiome affects Caenorhabditis elegans lifespan.

Author information

1
UCLA Department of Chemistry and Biochemistry and the Molecular Biology Institute, Los Angeles, CA 90095, USA.

Abstract

In a paper in BMC Biology Virk et al. show that Caenorhabditis elegans lifespan is extended in response to a diet of folate-deficient Escherichia coli. The deficiencies in folate biosynthesis were due to an aroD mutation, or treatment of E. coli with sulfa drugs, which are mimics of the folate precursor para-aminobenzoic acid. This study suggests that pharmacological manipulation of the gut microbiome folate status may be a viable approach to slow animal aging, and raises questions about folate supplementation.

PMID:
22849295
PMCID:
PMC3409036
DOI:
10.1186/1741-7007-10-66
[Indexed for MEDLINE]
Free PMC Article

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