Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Top Behav Neurosci. 2013;15:189-210. doi: 10.1007/7854_2012_220.

All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis.

Author information

1
Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, NIA/NIH Biomedical Research Center, Suite 100, 251 Bayview Blvd, Baltimore, MD, 21224, USA.

Abstract

Accumulating evidence from animal and human research shows exercise benefits learning and memory, which may reduce the risk of neurodegenerative diseases, and could delay age-related cognitive decline. Exercise-induced improvements in learning and memory are correlated with enhanced adult hippocampal neurogenesis and increased activity-dependent synaptic plasticity. In this present chapter we will highlight the effects of physical activity on cognition in rodents, as well as on dentate gyrus (DG) neurogenesis, synaptic plasticity, spine density, neurotransmission and growth factors, in particular brain-derived nerve growth factor (BDNF).

PMID:
22847651
PMCID:
PMC4565722
DOI:
10.1007/7854_2012_220
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center