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Diabetologia. 2012 Nov;55(11):2985-8. doi: 10.1007/s00125-012-2666-2. Epub 2012 Jul 31.

Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes.

Author information

1
Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, 900 Veteran Avenue, 24-130 Warren Hall, Los Angeles, CA 90095-7073, USA.

Abstract

AIMS/HYPOTHESIS:

The beta cell transcriptional factor musculoaponeurotic fibrosarcoma oncogene family A (MafA) regulates genes important for beta cell function. Loss of nuclear MafA has been implicated in beta cell dysfunction in animal models of type 2 diabetes. We sought to establish if nuclear MafA is less abundant in beta cell nuclei in humans with type 2 diabetes.

METHODS:

Pancreas obtained at surgery from five non-diabetic individuals and six individuals with type 2 diabetes was immunostained for insulin, glucagon and MafA.

RESULTS:

Beta cell nuclear MafA was markedly decreased in type 2 diabetes (1.6 ± 1.2% vs 46.3 ± 8.3%, p < 0.001).

CONCLUSIONS/INTERPRETATION:

Beta cell nuclear MafA is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.

PMID:
22847061
PMCID:
PMC3556170
DOI:
10.1007/s00125-012-2666-2
[Indexed for MEDLINE]
Free PMC Article

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