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Clin Calcium. 2012 Aug;22(8):1173-9. doi: CliCa120811731179.

[Magnesium and cardiac function].

[Article in Japanese]

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1
Department of Physiology, Tokyo Medical University, Japan.

Abstract

Free magnesium ion (Mg(2 + )) is involved in numerous processes of cardiac function. However, mechanism of regulation by Mg(2 + ) has not been fully understood. Extracellular Mg(2 + ) can act on the external surface of the cell membrane, whereas intracellular Mg(2 + ) can exert its effects via many different sites : various enzymes, intracellular organella and internal surface of the cell membrane. In this article, we will briefly review the extracellular and intracellular effects of Mg(2 + ) on each step of E-C coupling of cardiac myocytes, in an attempt to integrate them into cardiac function.

PMID:
22846352
DOI:
CliCa120811731179
[Indexed for MEDLINE]
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