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Eur J Neurosci. 2012 Oct;36(7):2941-8. doi: 10.1111/j.1460-9568.2012.08220.x. Epub 2012 Jul 30.

MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex.

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1
Henry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK. helen.scott@bristol.ac.uk

Abstract

Evidence suggests that the acquisition of recognition memory depends upon CREB-dependent long-lasting changes in synaptic plasticity in the perirhinal cortex.The CREB-responsive microRNA miR-132 has been shown to regulate synaptic transmission and we set out to investigate a role for this microRNA in recognition memory and its underlying plasticity mechanisms. To this end we mediated the specific overexpression of miR-132 selectively in the rat perirhinal cortex and demonstrated impairment in short-term recognition memory. This functional deficit was associated with a reduction in both long-term depression and long-term potentiation. These results confirm that microRNAs are key coordinators of the intracellular pathways that mediate experience-dependent changes in the brain. In addition, these results demonstrate a role for miR-132 in the neuronal mechanisms underlying the formation of short-term recognition memory.

PMID:
22845676
PMCID:
PMC3488600
DOI:
10.1111/j.1460-9568.2012.08220.x
[Indexed for MEDLINE]
Free PMC Article
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