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PLoS One. 2012;7(7):e41439. doi: 10.1371/journal.pone.0041439. Epub 2012 Jul 23.

Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats.

Author information

1
Internal Medicine Department, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil.

Abstract

INTRODUCTION:

Micronutrient deficiency is observed in heart failure patients. Taurine, for example, represents 50% of total free amino acids in the heart, and in vivo studies have linked taurine deficiency with cardiomyopathy.

METHODS:

Thirty-four male Wistar rats (body weight = 100 g) were weighed and randomly assigned to one of two groups: Control (C) or taurine-deficient (T (-)). Beta-alanine at a concentration of 3% was added to the animals' water to induce taurine deficiency in the T (-) group. On day 30, the rats were individually submitted to echocardiography; morphometrical and histopathological evaluation and metalloproteinase activity, oxidative stress and inflammation evaluation were performed. Tissue samples were collected to determine the taurine concentration in the heart.

RESULTS:

Taurine deficiency led to decreases in: ventricular wall thickness, left ventricle dry weight, myocyte sectional area, left ventricle posterior wall thickness and ventricular geometry. With regard to heart function, the velocity of the A wave, the ratio between the E and A wave, the ejection fraction, fractional shortening and cardiac output values were decreased in T (-) rats, suggesting abnormal diastolic and systolic function. Increased fibrosis, inflammation and increased activation of metalloproteinases were not observed. Oxidative stress was increased in deficient animals.

CONCLUSIONS:

These data suggest that taurine deficiency promotes structural and functional cardiac alterations with unique characteristics.

PMID:
22844478
PMCID:
PMC3402411
DOI:
10.1371/journal.pone.0041439
[Indexed for MEDLINE]
Free PMC Article

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