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Evid Based Complement Alternat Med. 2012;2012:981352. doi: 10.1155/2012/981352. Epub 2012 Jul 12.

Effectiveness of Mentha piperita in the Treatment of Infantile Colic: A Crossover Study.

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1
Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 301 Boa Vista, 52050-080 Recife, PE, Brazil.

Abstract

BACKGROUND:

Infantile colic is a distressing and common condition for which there is no proven standard treatment.

OBJECTIVE:

To compare the efficacy of Mentha piperita with simethicone in treatment for infantile colic.

METHODS:

A double-blind crossover study was performed with 30 infants attending IMIP, Recife, Brazil. They were randomized to use Mentha piperita or simethicone in the treatment of infantile colic during 7 days with each drug. Primary outcomes were mother_s opinion about responses to the treatment, number of daily episodes of colic, and time spent crying, measured by a chronometer. Mann-Whitney and chi-square tests were used to compare the results. This study was previously approved by the Ethical Committee in Research at IMIP.

RESULTS:

At baseline daily episodes of infantile colic was 3.9 (±1.1) and the mean crying time per day was 192 minutes (±51.6). At the end of the study daily episodes of colic fell to 1.6 (±0.6) and the crying duration decreased to 111 (±28) minutes. All mothers reported decrease of frequency and duration of the episodes of infantile colic and there were no differences between responses to Mentha piperita and simethicone.

CONCLUSIONS:

These findings suggest that Mentha piperita may be used to help control infantile colic. However, these results must be repeated by others studies.

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