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Tetrahedron Lett. 2012 Aug 8;53(32):4202-4205. Epub 2012 Jun 8.

Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring.

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Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center 101 Stephenson Parkway, Room 1000, University of Oklahoma, Norman, Oklahoma, 73019-5251, USA.


A collection of fungal isolates was obtained from a complex microbial mat, which occupied an iron-rich freshwater spring that feeds into Clear Creek, Golden, Colorado, USA. Two of the fungal isolates, a Glomeromycete (possible Entrophospora sp.) and a Dothideomycete (possible Phaeosphaeria sp.), were investigated for bioactive secondary metabolites. In total, six new compounds consisting of clearanols A-E (5, 6, 10-12) and disulochrin (7) were purified and their structures were determined. Disulochrin exhibited modest antibacterial activity against methicillin-resistant Staphylococcus aureus, whereas clearanol C showed weak inhibitory activity against Candida albicans biofilm formation.

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