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J Gerontol A Biol Sci Med Sci. 2012 Dec;67(12):1358-64. doi: 10.1093/gerona/gls157. Epub 2012 Jul 25.

Aging in the glomerulus.

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1
University of Michigan Health System, Division of Geriatrics, Department of Internal Medicine, 1560 MSRBII, Box 5676, Ann Arbor, MI 48109-5676, USA. wiggi@umich.edu

Abstract

Kidney function declines with age in the majority of the population. Although very few older people progress to end stage, the consequences of doing so are burdensome for the patient and very expensive for the society. Although some of the observed decline is likely due to changes in the vasculature, much is associated with the development of age-associated glomerulosclerosis. This article will review the well-established structural and functional changes in the glomerulus with age. The role of calorie restriction in modifying age-related pathology will be discussed. The importance of the podocyte as a critical cell in the aging process is considered using animal models and human biopsy material. Newer data on changes in gene expression driven by nuclear factor kappa beta (NFkB) and possible changes in biology in the glomerulus are discussed. The relationship between pathways involved in aging and the decline in kidney function is reviewed. There is speculation on the significance of these changes in relation to normal and pathological aging.

PMID:
22843670
PMCID:
PMC3636672
DOI:
10.1093/gerona/gls157
[Indexed for MEDLINE]
Free PMC Article
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