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Nat Med. 2012 Aug;18(8):1205-7. doi: 10.1038/nm.2844. Epub 2012 Jul 29.

Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.

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Institut de Biologie et Chimie des Protéines, Centre National de la Recherche Scientifique (CNRS) FRE 3310, Lyon, France; Université de Lyon 1, FRE 3310, Lyon, France.


Pressure-induced vasodilation (PIV) delays the decrease in cutaneous blood flow produced by local application of low pressure to the skin, a physiologically appropriate adjustment of local vasomotor function. Individuals without a normal PIV response have a high risk of ulceration. Here we demonstrate that acid-sensing ion channel 3 (Asic3) is an essential neuronal sensor for the vasodilation response to direct pressure in both humans and rodents and for protecting against pressure ulcers in mice.

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