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J Cancer Res Ther. 2012 Apr-Jun;8(2):297-9. doi: 10.4103/0973-1482.98994.

Primary amyloidosis with high grade transitional cell carcinoma of bladder: a rare case report.

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Department of Urology, Bombay Hospital Institute of Medical Sciences, Mumbai, India.


Primary amyloidosis of bladder is a rare disease that closely resembles bladder cancer on clinical presentation with painless gross hematuria. Pathologically this is a totally benign non-neoplastic lesion and its association with urothelial carcinoma of the bladder is rare. We herein report a 64-year-old diabetic male who has been treated for primary amyloidosis of bladder for the last 26 years presented recently with high-grade solid urothelial cancer with osseous metaplasia and sarcomatoid change of bladder with area of amyloid deposition.

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