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Am J Pathol. 2012 Oct;181(4):1142-6. doi: 10.1016/j.ajpath.2012.06.024. Epub 2012 Jul 27.

Prospective treatment of age-related diseases by slowing down aging.

Author information

1
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. blagosklonny@oncotarget.com

Abstract

Atherosclerosis, hypertension, obesity, diabetic complications, cancer, benign prostate hyperplasia, Alzheimer and Parkinson diseases, age-related macular degeneration, osteoarthritis, osteoporosis, and seborrheic keratosis are strongly associated with aging, implying a common underlying process. Each disease is treated separately and, in most cases, symptomatically. Suppression of aging itself should delay or treat all age-related diseases, thus increasing healthy life span and maximal longevity. But, is it possible to slow down aging? Recent evidence indicates that the target of rapamycin signaling pathway is involved in cellular senescence and organismal aging. Preclinical and clinical studies demonstrated the therapeutic effects of rapamycin in diverse age-related diseases. One simple reason why a single drug is indicated for so many age-related diseases is that it inhibits the aging process.

PMID:
22841821
DOI:
10.1016/j.ajpath.2012.06.024
[Indexed for MEDLINE]

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