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Early Hum Dev. 2013 Jan;89(1):21-5. doi: 10.1016/j.earlhumdev.2012.07.003. Epub 2012 Jul 25.

Reduction of catheter-related bloodstream infections in preterm infants by the use of catheters with the AgION antimicrobial system.

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1
Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Viale Morgagni, 85, 50134 Florence, Italy.

Abstract

OBJECTIVE:

The present study aims to assess if use of a silver zeolite-impregnated umbilical catheter (AgION technology) can decrease the occurrence of catheter-related bloodstream infection (CRBSIs) in preterm infants.

STUDY DESIGN:

Infants with gestational age<30weeks were randomized to receive an AgION impregnated or non-impregnated polyurethane umbilical venous catheter (UVC). The primary endpoint was the incidence of CRBSIs during the time the UVC was in place.

RESULTS:

We studied 86 infants, 41 of whom received the AgION catheter and 45 the non-impregnated catheter. During umbilical venous catheterization 2% of infants in the AgION group developed CRBSI in comparison with 22% of infants in the control group (p=0.005). AgION catheters were well tolerated and none of the patients showed signs attributable to silver toxicity.

CONCLUSIONS:

The AgION-impregnated UVCs were effective in decreasing the development of CRBSIs in preterm infants compared to non-impregnated polyurethane UVCs.

[Indexed for MEDLINE]

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