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Chem Biol. 2012 Jul 27;19(7):787-8. doi: 10.1016/j.chembiol.2012.07.006.

Babysitting flavin for biosynthesis.


Enzymes involved in natural product biosynthesis employ a variety of cofactors, reaction mechanisms, and substrate preferences to achieve remarkable chemical diversity found in nature. In this issue of Chemistry & Biology, Goldman and colleagues show how cofactor (FAD) binding affinity impacts the reaction mechanism and outcome of two related proteins, RebC and StaC, involved in indolocarbazoles biosynthesis.

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