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Anal Chim Acta. 2012 Aug 31;740:1-11. doi: 10.1016/j.aca.2012.06.024. Epub 2012 Jun 21.

Miniaturization through lab-on-a-chip: utopia or reality for routine laboratories? A review.

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Department of Analytical Chemistry and Food Technology, University of Castilla-La Mancha, E-13004 Ciudad Real, Spain.


Micro total analysis (μTAS), also called "lab-on-a-chip (LOC)" technology, promises solutions for high throughput and highly specific analysis for chemistry, biology and medicine, while consuming only tiny amounts of samples, reactants and space. This article reports selected contributions of LOC, which represent clear practical approaches for routine work, or presenting potentiality to be transferred to routine analytical laboratories. Taking into account the present LOC state-of-the-art, we identify various reasons for its scarce implementation in routine analytical laboratories despite its high analytical potential, as well as the probably main "niche" for successfully practical developments is suggested.


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