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Carbohydr Polym. 2012 Oct 1;90(2):870-4. doi: 10.1016/j.carbpol.2012.06.013. Epub 2012 Jun 17.

Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus.

Author information

1
State Key Laboratory of Dairy Biotechnology, Technology Center of Bright Dairy & Food Co. Ltd., Shanghai 200436, China. fanliuping@jiangnan.edu.cn

Abstract

The medicinal mushroom Inonotus obliquus has been used as a folk remedy for a long time in Russia and East-European countries to treat gastrointestinal cancer, cardiovascular disease and diabetes. In our study, a water-soluble polysaccharide (ISP2a) was successfully purified from I. obliquus by DEAE-Sepharose CL-6B and Sepharose CL-6B column chromatography. In vivo ISP2a had not only shown antitumor activity, but also could significantly enhance the immune response of tumor-bearing mice. In addition, ISP2a significantly enhanced the lymphocyte proliferation and increased the production of TNF-α. Results of these studies demonstrated that ISP2a had a potential application as natural antitumor agent with immunomodulatory activity.

PMID:
22840014
DOI:
10.1016/j.carbpol.2012.06.013
[Indexed for MEDLINE]

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