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Nat Neurosci. 2012 Jul 26;15(8):1061-2. doi: 10.1038/nn.3169.

DNA methylation in cognition comes of age.

Author information

1
Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, Massachusetts, USA.

Abstract

A study reveals that aged mice have decreased hippocampal expression of the DNA methyltransferase Dnmt3a2; re-expression in aged mice reverses memory deficits, and knockdown in young mice impairs memory formation.

PMID:
22837034
DOI:
10.1038/nn.3169
[Indexed for MEDLINE]

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