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Obesity (Silver Spring). 2012 Dec;20(12):2431-7. doi: 10.1038/oby.2012.162. Epub 2012 Jun 22.

Copy number variations associated with obesity-related traits in African Americans: a joint analysis between GENOA and HyperGEN.

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  • 1Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

Abstract

Obesity is a highly heritable trait and a growing public health problem. African Americans (AAs) are a genetically diverse, yet understudied population with a high prevalence of obesity (BMI >30 kg/m(2)). Recent studies based upon single-nucleotide polymorphisms (SNPs) have identified genetic markers associated with obesity. However, a large proportion of the heritability of obesity remains unexplained. Copy number variation (CNV) has been cited as a possible source of missing heritability in common diseases such as obesity. We conducted a CNV genome-wide association study of BMI in two African-American cohorts from Genetic Epidemiology Network of Arteriopathy (GENOA) and Hypertension Genetic Epidemiology Network (HyperGEN). We performed independent and identical association analyses in each study, then combined the results in a meta-analysis. We identified three CNVs associated with BMI, obesity, and other obesity-related traits after adjusting for multiple testing. These CNVs overlap the PARK2, GYPA, and SGCZ genes. Our results suggest that CNV may play a role in the etiology of obesity in AAs.

PMID:
22836685
PMCID:
PMC3484176
DOI:
10.1038/oby.2012.162
[PubMed - indexed for MEDLINE]
Free PMC Article
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