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Amino Acids. 2013 Feb;44(2):529-32. doi: 10.1007/s00726-012-1366-z. Epub 2012 Jul 27.

Preparation of 3-bromo-L-tyrosine and 3,5-dibromo-L-tyrosine.

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1
Department of Chemistry, University of Georgia, Athens, GA 30602, USA. rsphillips@chem.uga.edu

Abstract

L-Tyrosine is converted to 3-bromo-L-tyrosine in good yield by reaction with 1.2 equiv. of DMSO in HBr/AcOH, while reaction with 2.2 equiv. of DMSO under comparable conditions results in formation of 3,5-dibromo-L-tyrosine in good yield. This is the simplest, safest and most efficient method for the preparation of gram quantities of either 3-bromo-L-tyrosine or 3,5-dibromo-L-tyrosine.

PMID:
22836678
DOI:
10.1007/s00726-012-1366-z
[Indexed for MEDLINE]
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