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Dent Clin North Am. 2012 Jul;56(3):639-49. doi: 10.1016/j.cden.2012.05.005.

Regenerative endodontics: barriers and strategies for clinical translation.

Author information

1
Center for Craniofacial Regeneration, Columbia University, 630 West 168 Street, PH7E, New York, NY 10032, USA. jmao@columbia.edu

Abstract

Regenerative endodontics has encountered substantial challenges toward clinical translation. The adoption by the American Dental Association of evoked pulp bleeding in immature permanent teeth is an important step for regenerative endodontics. However, there is no regenerative therapy for most endodontic diseases. Simple recapitulation of cell therapy and tissue engineering strategies that are under development for other organ systems has not led to clinical translation in regeneration endodontics. Recent work using novel biomaterial scaffolds and growth factors that orchestrate the homing of host endogenous cells represents a departure from traditional cell transplantation approaches and may accelerate clinical translation.

PMID:
22835543
PMCID:
PMC4093795
DOI:
10.1016/j.cden.2012.05.005
[Indexed for MEDLINE]
Free PMC Article

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