Format

Send to

Choose Destination
Curr Opin Cell Biol. 2012 Oct;24(5):685-94. doi: 10.1016/j.ceb.2012.06.009. Epub 2012 Jul 24.

Contact inhibition (of proliferation) redux.

Author information

1
Massachusetts General Hospital Center for Cancer Research and Harvard Medical School Department of Pathology, Charlestown, MA, USA. mcclatch@helix.mgh.harvard.edu

Abstract

It has long been appreciated that proliferation of many cells is inhibited by density, a phenomenon that is often attributed to cell-cell contact. The basic properties of this phenomenon were established in the 1960s, along with the observation that such density-dependence was also lost in transformed cells. The mechanistic basis of contact inhibition of proliferation (CIP) has been slower to reveal itself. Here we discuss recent progress in elucidating the roles that cell-cell adhesion molecules play as receptors for CIP and in characterising the intracellular signaling pathways that mediate adhesion-dependent proliferative inhibition.

PMID:
22835462
DOI:
10.1016/j.ceb.2012.06.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center