Abstract
TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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AMP-Activated Protein Kinases / metabolism
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Animals
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Diabetic Nephropathies / metabolism*
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Estradiol / metabolism*
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Female
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Glucose / metabolism*
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Glucose Transport Proteins, Facilitative / metabolism
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Humans
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Male
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Mice
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Rats
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Sex Factors
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Signal Transduction
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Sodium-Glucose Transport Proteins / metabolism
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TOR Serine-Threonine Kinases / metabolism
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Testosterone / metabolism*
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Transforming Growth Factor beta / metabolism*
Substances
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Glucose Transport Proteins, Facilitative
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Sodium-Glucose Transport Proteins
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Transforming Growth Factor beta
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Testosterone
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Estradiol
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TOR Serine-Threonine Kinases
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AMP-Activated Protein Kinases
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Glucose