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Semin Nephrol. 2012 May;32(3):261-8. doi: 10.1016/j.semnephrol.2012.04.005.

Sugar, sex, and TGF-β in diabetic nephropathy.

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1
Center for Renal Translational Medicine, University of California San Diego/Veterans Affairs San Diego Healthcare System, La Jolla, CA 92093-0711, USA.

Abstract

TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

PMID:
22835457
PMCID:
PMC3442601
DOI:
10.1016/j.semnephrol.2012.04.005
[Indexed for MEDLINE]
Free PMC Article
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