Abstract
Honokiol (3',5-di-(2-propenyl)-1,1'-biphenyl-2,4'-diol) is a bioactive natural product derived from Magnolia spp. Recent studies have demonstrated anti-inflammatory, anti-angiogenic, anti-oxidative and anticancer properties of honokiol in vitro and in preclinical models. Honokiol targets multiple signaling pathways including nuclear factor kappa B (NF-κB), signal transducers and activator of transcription 3 (STAT3), epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (m-TOR), which have great relevance during cancer initiation and progression. Furthermore, pharmacokinetic profile of honokiol has revealed a desirable spectrum of bioavailability after intravenous administration in animal models, thus making it a suitable agent for clinical trials. In this review, we discuss recent data describing the molecular targets of honokiol and its anti-cancer activities against various malignancies in pre-clinical models. Evaluation of honokiol in clinical trials will be the next step towards its possible human applications.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use
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Antineoplastic Agents, Phytogenic* / pharmacokinetics
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Antineoplastic Agents, Phytogenic* / pharmacology
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Antineoplastic Agents, Phytogenic* / therapeutic use
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Apoptosis / drug effects
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Biphenyl Compounds* / pharmacokinetics
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Biphenyl Compounds* / pharmacology
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Biphenyl Compounds* / therapeutic use
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Cell Line, Tumor
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ErbB Receptors / metabolism
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Humans
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Lignans* / pharmacokinetics
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Lignans* / pharmacology
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Lignans* / therapeutic use
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Magnolia
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Mice
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NF-kappa B / metabolism
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Neoplasms / drug therapy*
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Neoplasms / prevention & control
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Plant Preparations / pharmacology
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Plant Preparations / therapeutic use
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Rats
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STAT3 Transcription Factor / metabolism
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Signal Transduction / drug effects
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TOR Serine-Threonine Kinases / metabolism
Substances
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Anti-Inflammatory Agents
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Antineoplastic Agents, Phytogenic
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Biphenyl Compounds
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Lignans
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NF-kappa B
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Plant Preparations
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STAT3 Transcription Factor
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STAT3 protein, human
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honokiol
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MTOR protein, human
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EGFR protein, human
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ErbB Receptors
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TOR Serine-Threonine Kinases