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Int J Hyperthermia. 2012;28(6):509-17. doi: 10.3109/02656736.2012.695427. Epub 2012 Jul 26.

Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies.

Author information

1
Department of Cell Biology and Genetics, Cancer Genomics Centre, Erasmus Medical Centre, Rotterdam, The Netherlands.

Abstract

Local hyperthermia is an effective treatment modality to augment radio- and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken together, these results provide the rationale for the development of novel anti-cancer therapies that combine hyperthermia-induced homologous recombination deficiency with the systemic administration of drugs that specifically affect the viability of homologous recombination deficient cells and/or inhibit the heat-shock response, to locally sensitise cancer cells to DNA damaging agents.

PMID:
22834701
DOI:
10.3109/02656736.2012.695427
[Indexed for MEDLINE]

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