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Curr Opin Pharmacol. 2012 Dec;12(6):736-41. doi: 10.1016/j.coph.2012.07.002. Epub 2012 Jul 23.

Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer.

Author information

1
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA. natalia.riobo@jefferson.edu

Abstract

The connection between the Hedgehog (HH) pathway and cholesterol has been recognized since the early days that shaped our current understanding of this unique pathway. Cholesterol and related lipids are intricately linked to HH signaling: from the role of cholesterol in HH biosynthesis to the modulation of HH signal reception and transduction by other sterols, passing by the phylogenetic relationships among many components of the HH pathway that resemble or contain lipid-binding domains. Here I review the connections between HH signaling, cholesterol and its derivatives and analyze the potential implications for HH-dependent cancers.

PMID:
22832232
PMCID:
PMC3675894
DOI:
10.1016/j.coph.2012.07.002
[Indexed for MEDLINE]
Free PMC Article

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