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Immunol Lett. 1990 Aug;25(1-3):71-6.

Non-CS pre-erythrocytic protective antigens.

Author information

1
Biomedical Research Institute, Rockville, MD 20852.

Abstract

Three novel non-CS antigens have been identified on P. falciparum and P. berghei sporozoites and exoerythrocytic parasites. CSP-2 is a sporozoite surface protein common to P. falciparum and P. berghei that elicits antibody-mediated protection, and is also found within P. berghei EE parasites. LSA is a P. falciparum EE-specific antigen localized within the parasitophorous vacuole. LSA-2 is a P. berghei EE-specific antigen, localized on the parasitophorous vacuole membrane, that protected mice to P. berghei sporozoite challenge, and elicited cytotoxic T cells that killed P. berghei EE parasites in vitro.

PMID:
2283163
DOI:
10.1016/0165-2478(90)90094-7
[Indexed for MEDLINE]

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