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FEMS Microbiol Lett. 1990 Oct;60(1-2):235-9.

Initiation of growth in pbpAts and rodAts mutants of Escherichia coli.

Author information

1
Centro de BiologĂ­a Molecular CSIC-UAM, Facultad de Ciencias, Madrid, Spain.

Abstract

Escherichia coli strains harbouring pbpAts mutations are particularly sensitive to functional alterations of penicillin-binding protein 2 (PBP 2) at the initiation of growth. Shift-up to 42 degrees C results in the inability of cells to reach a steady rate of growth and division. Furthermore, a very high proportion of cells generate minicell-like structures which are pinched-off through a process requiring the activity of penicillin-binding protein 3 (PBP 3).

PMID:
2283038
DOI:
10.1016/0378-1097(90)90378-4
[Indexed for MEDLINE]

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