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FEMS Microbiol Lett. 1990 Oct;60(1-2):169-72.

Haemin inhibits the trypsin-like enzyme activity of Porphyromonas gingivalis W83.

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MRC Dental Research Unit, London Hospital Medical College, U.K.


The effect of haemin and related porphyrins on the activity of the trypsin-like enzyme activity in cell sonicates of Porphyromonas gingivalis was examined using a spectrophotometric assay and by following the degradation of human IgG. Haemin was inhibitory in both assay systems and the effect was shown to be reversible. The high concentration of haemin accumulated by P. gingivalis may protect the organism against autodegradative effects of the trypsin-like protease.

[Indexed for MEDLINE]

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