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PLoS One. 2012;7(7):e41022. doi: 10.1371/journal.pone.0041022. Epub 2012 Jul 19.

Heart failure and preserved left ventricular function: long term clinical outcome.

Author information

  • 1Heart Institute, Hadassah University Hospital, Jerusalem, Israel. igotsman@bezeqint.net

Abstract

BACKGROUND:

Patients with heart failure (HF) have a poor prognosis. The proportion of patients with HF and preserved left ventricular function (LVF) is increasing. Long term prognosis of HF with preserved LVF may not be so benign.

OBJECTIVES:

To evaluate the long term clinical outcome of patients with HF and preserved LVF and predictors of outcome.

METHODS:

We prospectively evaluated 309 patients hospitalized with a definite clinical diagnosis of HF. Patients were followed for a mean of 6.5 years for clinical outcome.

RESULTS:

More than a third (36%) of the patients had preserved systolic LVF based on echocardiography. The long term survival rate in this group was poor and not significantly different from patients with reduced LVF (28% vs 23% respectively, P=0.2). The adjusted survival rate by Cox regression analysis was also not significantly different (hazard ratio 1.16, 95% confidence interval 0.87-1.55, P=0.31). The event free survival from death or heart failure re-hospitalization was also low in both groups and not significantly different between patients with preserved vs. reduced LVF (12% vs. 10% respectively, P=0.2). Predictors of mortality in patients with preserved LVF were age, functional capacity and serum urea levels.

CONCLUSIONS:

The long term clinical outcome of patients with heart failure and preserved LVF is poor and not significantly different from patients with reduced LVF.

PMID:
22829907
PMCID:
PMC3400584
DOI:
10.1371/journal.pone.0041022
[PubMed - indexed for MEDLINE]
Free PMC Article
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