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Epidemiology. 2012 Sep;23(5):742-50.

Exposure to cats and dogs, and symptoms of asthma, rhinoconjunctivitis, and eczema.

Collaborators (158)

Aït-Khaled N, Anderson HR, Asher MI, Beasley R, Björkstén B, Brunekreef B, Crane J, Ellwood P, Forastiere F, Flohr C, García-Marcos L, Foliaki S, Keil U, Lai CK, Mallol J, Mitchell EA, Montefort S, Odhiambo J, Pearce N, Robertson CF, Stewart AW, Strachan DP, von Mutius E, Weiland SK, Weinmayr G, Williams H, Wong G, Asher MI, Clayton TO, Ellwood P, Mitchell EA, Stewart AW, Baena-Cagnani CE, Gómez M, Howitt ME, Weyler J, Pinto-Vargas R, Cunha AJ, de Freitas Souza L, Kuaban C, Ferguson A, Rennie D, Staning P, Aguilar P, Amarales L, Benavides LA, Contreras A, Chen YZ, Zhou T, Kunii O, Li Pan Q, Zhong NS, Aristizábal G, Cepeda AM, Ordoñez GA, Koffi BN, Bustos C, Riikjärv MA, Melaku K, Sa'aga-Banuve R, Pekkanen J, Vlaski E, Hypolite IE, Wong G, Novák Z, Zsigmond G, Awasthi S, Bhave S, Hanumante NM, Jain KC, Joshi MK, Khatav VA, Mantri SN, Pherwani AV, Rego S, Sabir M, Salvi S, Setty G, Sharma SK, Sukumaran TU, Suresh Babu PS, Kartasasmita CB, Konthen P, Suprihati W, Masjedi MR, Steriu A, Odajima H, al-Momen JA, Imanalieva C, Kudzyte J, Quah BS, Teh KH, Baeza-Bacab M, Barragán-Meijueiro M, Del-Río-Navarro BE, García-Almaráz R, González-Díaz SN, Linares-Zapién FJ, Merida-Palacio JV, Ramírez- Chanona N, Romero-Tapia S, Romieu I, Bouayad Z, Asher MI, MacKay R, Moyes C, Pattemore P, Pearce N, Onadeko BO, Cukier G, Chiarella P, Cua-Lim F, Brêborowicz A, Lis G, Câmara R, Lopes dos Santos JM, Nunes C, Rosado J, Fuimaono P, Goh DY, Zar HJ, Blanco-Quirós A, Busquets RM, Carvajal-Urueña I, García-Hernández G, García-Marcos L, González Díaz C, López-Silvarrey Varela A, Morales Suárez- Varela MM, Pérez-Yarza EG, Musa OA, Al-Rawas O, Mohammad S, Mohammad Y, Tabbah K, Huang JL, Kao CC, Trakultivakorn M, Vichyanond P, Iosefa T, Windom HH, Strachan D, Holgado D, Lapides MC, Aley O, Sole D, Sears M, Anderson R, Aguirre V, Mallol J, Barba S, Lai CK, Shah J, Baratawidjaja K, Nishima S, Tuuau-Potai N, Lee BW, Sony El.

Author information

1
Institute for Risk Assessment Sciences and Julius Center for Health Sciences and Primary Care, University Medical Center Universiteit Utrecht, The Netherlands. b.brunekreef@uu.nl

Abstract

BACKGROUND:

Associations between exposure to cats and dogs and respiratory and allergic outcomes in children have been reported in affluent countries, but little is known about such associations in less-affluent countries.

METHODS:

The International Study of Asthma and Allergies in Childhood, phase 3 was carried out in children aged 6-7 years and adolescents aged 13-14 years across the world. Questions about cats and dogs in the home were included in an additional questionnaire. Using logistic regression, we investigated the association between such exposures and symptoms of asthma, rhinoconjunctivitis, and eczema. Adjustments were made for sex, region of the world, language, gross national income per capita, and 10 other covariates.

RESULTS:

Among children (6-7 years of age), cat exposure in the first year of life was associated with current symptoms of asthma, wheeze, rhinoconjunctivitis, and eczema, especially in less-affluent countries. Among adolescents (13-14 years of age), we found a positive association between exposure to cats or dogs and symptom prevalence in more-affluent and less-affluent countries. The global multivariate odds ratios for children with complete covariate data were 1.17 (95% confidence interval = 1.08-1.29) for current symptoms of asthma, 1.13 (1.05-1.23) for rhinoconjunctivitis, and 1.38 (1.26-1.52) for eczema. Smaller odds ratios were found for exposure to only dogs. Exposure to only cats was associated with eczema.

CONCLUSION:

Early-life exposure to cats is a risk factor for symptoms of asthma, rhinoconjunctivitis, and eczema in 6- to 7-year-old children, especially in less-affluent countries. Current exposure to cats and dogs combined, and only to dogs, is a risk factor for symptom reporting by 13- to 14-year-old adolescents worldwide.

PMID:
22828662
DOI:
10.1097/EDE.0b013e318261f040
[Indexed for MEDLINE]

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