Format

Send to

Choose Destination
Br J Cancer. 2012 Jul 24;107(3):406-7. doi: 10.1038/bjc.2012.97.

That the effects of smoking should be measured in pack-years: misconceptions 4.

Abstract

Lung cancer incidence in smokers is roughly proportional to dose rate (cigarettes per day) but increases much more rapidly with duration of smoking. The assumption that the incidence rate is proportional to total lifetime dose (the product of dose rate and duration) has been known to be wrong for many years, but total dose in pack-years is still often included, either alone or together, with more fundamental parameters such as dose rate, in regression analysis of epidemiological data. This is mathematically unnecessary and scientifically unhelpful.

PMID:
22828655
PMCID:
PMC3405232
DOI:
10.1038/bjc.2012.97
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center