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J Sports Med Phys Fitness. 2012 Aug;52(4):448-54.

The effects of different exercise intensity on myokine and angiogenesis factors.

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Department of Physical Education, College of Sports Science, Dong-A University, Busan, Korea.



Myokines and angiogenesis factors, studies on trainings according to the difference of exercise intensity are not sufficient, and it has not been elucidated. Particularly, studies on the effect of resistance exercise according to the intensity of resistance exercise on blood myokines and angiogenesis may be essential in the metabolic process of angiogenesis and the formation of muscle.


The subjects of our studies were healthy male college students (N.=30) randomly assigned to the high intensity exercise group (N.=10), the moderate intensity exercise group (N.=10), and the control group (N.=10). The study was performed after obtaining a consent in advance, and the approval from the Institutional Review Board of Dong-A University Hospital. In the body composition test, height, weight, BMI (body mass index), %fat, and LBM (lean body mass) were measured by electric impedance. In blood analysis, myokines (interleukin (IL)-6, IL-8, IL-15) and angiogenesis factors (vascular endothelial growth factor (VEGF), angiopoietin (Ang)1, follistatin (FLRG)) were analyzed by ELISA methods.


The results show %body fat and LBM of the three groups were significantly different (P<0.05). IL-6 and IL-8 of the three groups were significantly different (P<0.05). Particularly, IL-8 of RE60 (60% of 1RM) was shown to be significantly higher than other groups (P<0.05). IL-15 also showed significant differences with time (P<0.05). In addition, VEGF and Ang 1 showed significant differences with time (P<0.05), nonetheless, FLRG did not showed statistical differences.


Many of muscle contraction through 8 weeks resistance exercise exerted positive effects on the concentration of blood myokines as well as angiogenesis. Particularly, in regard to blood myokines, moderate intensity exercise were more effective than high intensity exercise, which is considered to be due to that continuous muscle contraction of moderate intensity exercises exerted more positive effects on the elevation of the concentration of myokines than less muscle contraction of high intensity exercise.

[Indexed for MEDLINE]

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