Format

Send to

Choose Destination
BMC Evol Biol. 2012 Jul 24;12:122. doi: 10.1186/1471-2148-12-122.

Adaptive evolution of Toll-like receptor 5 in domesticated mammals.

Author information

1
School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington LE12 5RD, UK.

Abstract

BACKGROUND:

Previous studies have proposed that mammalian toll like receptors (TLRs) have evolved under diversifying selection due to their role in pathogen detection. To determine if this is the case, we examined the extent of adaptive evolution in the TLR5 gene in both individual species and defined clades of the mammalia.

RESULTS:

In support of previous studies, we find evidence of adaptive evolution of mammalian TLR5. However, we also show that TLR5 genes of domestic livestock have a concentration of single nucleotide polymorphisms suggesting a specific signature of adaptation. Using codon models of evolution we have identified a concentration of rapidly evolving codons within the TLR5 extracellular domain a site of interaction between host and the bacterial surface protein flagellin.

CONCLUSIONS:

The results suggest that interactions between pathogen and host may be driving adaptive change in TLR5 by competition between species. In support of this, we have identified single nucleotide polymorphisms (SNP) in sheep and cattle TLR5 genes that are co-localised and co-incident with the predicted adaptive codons suggesting that adaptation in this region of the TLR5 gene is on-going in domestic species.

PMID:
22827462
PMCID:
PMC3483281
DOI:
10.1186/1471-2148-12-122
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center