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J Clin Periodontol. 2012 Sep;39(9):879-86. doi: 10.1111/j.1600-051X.2012.01922.x. Epub 2012 Jul 25.

Influence of hyperbaric oxygen therapy on peri-implant bone healing in rats with alloxan-induced diabetes.

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1
Department of Periodontology, School of Dentistry, Pontific Catholic University of Minas Gerais, Belo Horizonte, Brazil.

Abstract

AIM:

The influence of hyperbaric oxygen therapy (HBOT) on peri-implant bone healing in rats with alloxan-induced type-1 diabetes was studied.

MATERIALS AND METHODS:

Forty-eight male rats were randomly divided into six groups: (1) healthy rats (HR) that received no HBOT; (2) HR that underwent 10 sessions of HBOT before implant installation; (3) HR that underwent 10 sessions of HBOT after implant installation; (4) rats with induced diabetes (DR) without HBOT; (5) DR that underwent 10 sessions of HBOT before implant installation; (6) DR that underwent 10 sessions of HBOT after implant installation. A screw-shaped titanium implant was inserted into the femur. The animals were killed 28 days after implantation. The percentage of bone-to-implant contact (BIC) within the implant threads was evaluated.

RESULTS:

Lower BIC was observed in DR (35.35 ± 18.04) compared with the HR (69.07 ± 09.01) (p = 0.001). However, with HBOT, either before or after implantation, BIC was increased in DR. HBOT before implantation was p = 0.03; HBOT after implantation was p = 0.08. This increase reversed the negative effect of diabetes; therefore, the differences between DR and HR were not significant with HBOT (p ≥ 0.21).

CONCLUSION:

HBOT, either before or after implantation, increased the BIC in DR to the level of HR.

[Indexed for MEDLINE]

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