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Cereb Cortex. 2013 Sep;23(9):2261-8. doi: 10.1093/cercor/bhs213. Epub 2012 Jul 23.

Mapping the human cortical surface by combining quantitative T(1) with retinotopy.

Author information

1
Birkbeck/UCL Centre for NeuroImaging, 26 Bedford Way, London WC1H 0AP, UK. m.sereno@ucl.ac.uk

Abstract

We combined quantitative relaxation rate (R1= 1/T1) mapping-to measure local myelination-with fMRI-based retinotopy. Gray-white and pial surfaces were reconstructed and used to sample R1 at different cortical depths. Like myelination, R1 decreased from deeper to superficial layers. R1 decreased passing from V1 and MT, to immediately surrounding areas, then to the angular gyrus. High R1 was correlated across the cortex with convex local curvature so the data was first "de-curved". By overlaying R1 and retinotopic maps, we found that many visual area borders were associated with significant R1 increases including V1, V3A, MT, V6, V6A, V8/VO1, FST, and VIP. Surprisingly, retinotopic MT occupied only the posterior portion of an oval-shaped lateral occipital R1 maximum. R1 maps were reproducible within individuals and comparable between subjects without intensity normalization, enabling multi-center studies of development, aging, and disease progression, and structure/function mapping in other modalities.

KEYWORDS:

MT; myelination; parcellation; surface reconstruction; visual areas

PMID:
22826609
PMCID:
PMC3729202
DOI:
10.1093/cercor/bhs213
[Indexed for MEDLINE]
Free PMC Article

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