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Gut Microbes. 2012 Sep-Oct;3(5):460-2. Epub 2012 Jul 24.

Ready…aim…fire into the lumen: a new role for enterocyte microvilli in gut host defense.

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1
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA.

Abstract

Recent studies from our laboratory revealed that enterocyte brush border microvilli release small vesicles laden with host defense machinery into the intestinal lumen. In this addendum, we introduce a multi-faceted model for the function of these lumenal vesicles in the gut; we also consider some of the important unanswered questions that must be addressed in order to develop our understanding of this novel aspect of innate intestinal immunity.

PMID:
22825496
PMCID:
PMC3466500
DOI:
10.4161/gmic.21247
[Indexed for MEDLINE]
Free PMC Article
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