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Curr Opin Pharmacol. 2012 Dec;12(6):710-6. doi: 10.1016/j.coph.2012.06.011. Epub 2012 Jul 21.

Regulation of cholesterol biosynthesis and cancer signaling.

Author information

1
Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

Abstract

Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.

PMID:
22824431
PMCID:
PMC3504641
DOI:
10.1016/j.coph.2012.06.011
[Indexed for MEDLINE]
Free PMC Article

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