Send to

Choose Destination
See comment in PubMed Commons below
Ann N Y Acad Sci. 2012 Jul;1262:118-26. doi: 10.1111/j.1749-6632.2012.06647.x.

The neuroimmune connection interferes with tissue regeneration and chronic inflammatory disease in the skin.

Author information

Center for Internal Medicine and Dermatology, Charité-University Medicine, Berlin, Germany.


Research over the past decades has revealed close interactions between the nervous and immune systems that regulate peripheral inflammation and link psychosocial stress with chronic somatic disease. Besides activation of the sympathetic and the hypothalamus-pituitary-adrenal axis, stress leads to increased neurotrophin and neuropeptide production in organs at the self-environment interface. The scope of this short review is to discuss key functions of these stress mediators in the skin, an exemplary stress-targeted and stress-sensitive organ. We will focus on the skin's response to acute and chronic stress in tissue regeneration and pathogenesis of allergic inflammation, psoriasis, and skin cancer to illustrate the impact of local stress-induced neuroimmune interaction on chronic inflammation.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center