Format

Send to

Choose Destination
Addict Biol. 2013 Jan;18(1):50-3. doi: 10.1111/j.1369-1600.2012.00479.x. Epub 2012 Jul 24.

Optogenetic inhibition of cocaine seeking in rats.

Author information

1
Department of Neurosciences, Medical University of South Carolina, Charleston, 29425, USA.

Abstract

Inhibitory optogenetics was used to examine the roles of the prelimbic cortex (PL), the nucleus accumbens core (NAcore) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno-associated virus containing halorhodopsin or archaerhodopsin. After 12 days of cocaine self-administration, followed by extinction training, animals underwent reinstatement testing along with the presence/absence of optically induced inhibition via laser light. Bilateral optical inhibition of the PL, NAcore or the PL fibers in the NAcore inhibited the reinstatement of cocaine seeking.

PMID:
22823160
PMCID:
PMC3578202
DOI:
10.1111/j.1369-1600.2012.00479.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center