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Br J Clin Pharmacol. 2013 Mar;75(3):799-804. doi: 10.1111/j.1365-2125.2012.04394.x.

Flurbiprofen concentration in soft tissues is higher after topical application than after oral administration.

Author information

1
Department of Sports Medicine and Joint Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

Abstract

AIM:

To compare tissue concentrations of flurbiprofen resulting from topical application and oral administration according to the regulatory approved dosing guidelines.

METHOD:

Sixteen patients were included in this study. Each patient was randomly assigned to the topical application or oral administration group. In each group, a pair of tapes or a tablet, containing a total of 40 mg flurbiprofen, was administered twice at 16 and 2 h before the surgery.

RESULTS:

The flurbiprofen concentration in the fat, tendon, muscle and periosteum tissues was significantly higher (P < 0.0330) after topical application (992 ng g⁻¹ [95% CI 482, 1503], 944 [95% CI 481, 1407], 492 [95% CI 248, 735], and 455 [95% CI 153, 756], respectively) than after oral administration (150 ng g⁻¹ [95% CI 84, 217], 186 [95% CI 118, 254], 82 [95% CI 49, 116],and 221 [95% CI, 135, 307], respectively).

CONCLUSION:

Topical application is an effective method to deliver flurbiprofen to the human body, particularly to soft tissues near the body surface.

PMID:
22822928
PMCID:
PMC3575946
DOI:
10.1111/j.1365-2125.2012.04394.x
[Indexed for MEDLINE]
Free PMC Article
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