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Zhong Yao Cai. 2012 Feb;35(2):296-9.

[Preparation and physiochemical properties of curcumin-loaded lipid cubic liquid crystalline nanoparticles].

[Article in Chinese]

Author information

1
School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. suxunz@yahoo.com.cn

Abstract

OBJECTIVE:

To prepare curcumin-loaded lipid cubic liquid crystalline nanoparticles and evaluate its physiochemical properties.

METHODS:

The nanoparticles were prepared using hot and high-pressure homogenization. The prescription and preparation process were optimized by uniform design with drug loading and entrapment efficiency as indexes.

RESULTS:

The nanoparticles were spherical under transmission electron microscope (TEM) with average particle size of 176.1 nm, zeta potential of -25.19 mV, average drug loading of (1.5 +/- 0.2)% and entrapment efficiency of (95 +/- 1.8)%. The release equation: In (1-Q) = -0.0251t-0.0075. The cumulative release percentage was 60% at 36 h in vitro.

CONCLUSION:

The obtained curcumin-loaded lipid cubic liquid crystalline nanoparticles shows high entrapment efficiency and good sustain release property.

PMID:
22822677
[Indexed for MEDLINE]
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