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Chem Commun (Camb). 2012 Sep 4;48(68):8595-7. doi: 10.1039/c2cc33565d. Epub 2012 Jul 20.

Time-gated luminescence microscopy with responsive nonmetal probes for mapping activity of protein kinases in living cells.

Author information

1
Institute of Chemistry, University of Tartu, 14A Ravila St., 50411 Tartu, Estonia.

Abstract

A photoluminescence probe ARC-1185, possessing both high affinity towards basophilic protein kinases (PKs) and microsecond-scale luminescence lifetime when associated with a kinase, was used for the mapping of ARC-1185-PK complexes in living cells with time-gated luminescence microscopy.

PMID:
22822483
PMCID:
PMC3415249
DOI:
10.1039/c2cc33565d
[Indexed for MEDLINE]
Free PMC Article

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