Format

Send to

Choose Destination
J Biol Chem. 2012 Sep 14;287(38):31624-32. doi: 10.1074/jbc.R112.349068. Epub 2012 Jul 20.

Ryanodine receptors: structure and function.

Author information

1
Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver V6T 1Z3, Canada. filip.vanpetegem@gmail.com

Abstract

Ryanodine receptors (RyRs) are huge ion channels that are responsible for the release of Ca(2+) from the sarco/endoplasmic reticulum. RyRs form homotetramers with a mushroom-like shape, consisting of a large cytoplasmic head and transmembrane stalk. Ca(2+) is a major physiological ligand that triggers opening of RyRs, but a plethora of modulatory proteins and small molecules in the cytoplasm and sarco/endoplasmic reticulum lumen have been recognized. Over 300 mutations in RyRs are associated with severe skeletal muscle disorders or triggered cardiac arrhythmias. With the advent of high-resolution structures of individual domains, many of these can be mapped onto the three-dimensional structure.

PMID:
22822064
PMCID:
PMC3442496
DOI:
10.1074/jbc.R112.349068
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center