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Peptides. 2012 Sep;37(1):171-3. doi: 10.1016/j.peptides.2012.07.012. Epub 2012 Jul 20.

Neuroprotection of apelin and its signaling pathway.

Author information

1
Department of Neurology, Jining Medical University, Jining City, Shandong Province, PR China. apple9red@yahoo.com.cn

Abstract

Apelin was initially isolated from bovine stomach and is an endogenous neuropeptide. It is a native ligand of the apelin receptor (APJ). Some research has found that apelin peptides alter blood pressure, feeding behavior, and pituitary hormone release. However, a new neuroprotective effect of apelin peptides was only recently discovered. This review summarizes the evidence of apelin-neuroprotection, which has the potential to cure acute and chronic neurological diseases.

PMID:
22820556
DOI:
10.1016/j.peptides.2012.07.012
[Indexed for MEDLINE]

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