Format

Send to

Choose Destination
Dev Biol. 2012 Sep 15;369(2):340-8. doi: 10.1016/j.ydbio.2012.07.008. Epub 2012 Jul 20.

FGF9-Pitx2-FGF10 signaling controls cecal formation in mice.

Author information

1
Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Children's Hospital Los Angeles, CA 90027, USA.

Abstract

Fibroblast growth factor (FGF) signaling to the epithelium and mesenchyme mediated by FGF10 and FGF9, respectively, controls cecal formation during embryonic development. In particular, mesenchymal FGF10 signals to the epithelium via FGFR2b to induce epithelial cecal progenitor cell proliferation. Yet the precise upstream mechanisms controlling mesenchymal FGF10 signaling are unknown. Complete deletion of Fgf9 as well as of Pitx2, a gene encoding a homeobox transcription factor, both lead to cecal agenesis. Herein, we used mouse genetic approaches to determine the precise contribution of the epithelium and/or mesenchyme tissue compartments in this process. Using tissue compartment specific Fgf9 versus Pitx2 loss of function approaches in the gut epithelium and/or mesenchyme, we determined that FGF9 signals to the mesenchyme via Pitx2 to induce mesenchymal Fgf10 expression, which in turn leads to epithelial cecal bud formation.

PMID:
22819677
PMCID:
PMC3725282
DOI:
10.1016/j.ydbio.2012.07.008
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Publication types

MeSH terms

Substances

Grant support

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center